Development of New CHM Mouse Models
Dr. Malia Edwards
Dr. Abigail Fahim
Dr. Kathleen Boesze-Battaglia
Malia Edwards, PhD
Associate Professor of Ophthalmology
Wilmer Eye Institute, Johns Hopkins Medicine, Baltimore, MD
Abigail Fahim, MD, PhD
Assistant Professor Ophthalmology and Visual Sciences
Kellogg Eye Center, University of Michigan, Ann Arbor, MI
Kathleen Boesze-Battaglia, PhD
Professor of Biochemistry and Biophysics
University of Pennsylvania, Philadelphia, PA
Lay Abstract
This project aims to better define the clinical and histological pathology of choroideremia by studying choroideremia conditional knock out mice. The investigators will be creating different mice by targeting different cell types to help determine which model best replicates the progression of retinal and RPE degeneration in choroideremia patients. The study will involve clinical imaging and vision testing of the mice at various ages followed by careful assessment of the retinal structure. This will determine what aspects of choroideremia are accurately mimicked in the mouse models, information that will be valuable in testing therapies.
Key Findings
This research is currently underway. Key findings will be published upon research conclusion.
CRF is registered as a US 501(c)3 nonprofit organization EIN: 04-3511754
Our mission is to raise funds in support of scientific research leading to a treatment or cure of choroideremia, a hereditary retinal-degenerative disease that causes blindness; to educate people affected by the disease; and to inform the public.
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